Pharmaceutical intermediate material characteristics
Pharmaceutical intermediates are actually some chemical raw materials or chemical products used in the process of drug synthesis. This chemical product does not require a production license for drugs and can be produced in ordinary chemical plants as long as it reaches some level. , Can be used for the synthesis of drugs.
Characteristics of pharmaceutical intermediate dryer equipment
The double-cone rotary vacuum dryer is a drying equipment integrating mixing and vacuum drying. The process of vacuum drying is to place the dried material in a sealed cylinder, and evacuate it with a vacuum system while continuously heating the dried material, so that the water inside the material diffuses to the surface through the pressure difference or concentration difference, and the water molecules (or other Non-condensable gas) obtain sufficient kinetic energy on the surface of the material, diffuse to the low-pressure space of the vacuum chamber after overcoming the mutual attraction between the molecules, and be pumped away by the vacuum pump to complete the separation from the solid. Therefore, the double cone rotary vacuum dryer shows the following characteristics:
(1) In the process of vacuum drying, the pressure in the cylinder is always lower than atmospheric pressure, the number of gas molecules is small, the density is low, and the oxygen content is low, so it can dry drugs that are easily oxidized and reduce the chance of material contamination.
(2) Because the temperature of moisture in the vaporization process is proportional to the steam pressure, when vacuum drying, the moisture in the material can be vaporized at low temperature to achieve low temperature drying, especially suitable for the production of pharmaceuticals with heat-sensitive materials.
(3) Vacuum drying can eliminate the surface hardening phenomenon that is easily caused by atmospheric hot air drying. This is because the pressure difference between the vacuum drying material and the surface is large. Under the effect of the pressure gradient, the moisture quickly moves to the surface, and no surface will appear. hardening.
(4) Due to the small temperature gradient between the inside and outside of the material during vacuum drying, the moisture can be moved and collected by itself due to reverse osmosis, effectively overcoming the loss caused by hot air drying.
The theory shows that the equipment also has the following characteristics: (1) constant heating temperature, increase the vacuum degree, speed up; (2) constant vacuum degree, increase the heating temperature, speed up; (3) both increase the vacuum degree and increase the heating temperature , The rate is greatly accelerated. (4) The heating medium can be hot water or steam (steam pressure is 0.40-0.50Mpa); (5) The inner wall of the dryer adopts arc transition to avoid hygienic dead ends and solvent condensation and condensation to drip the pollutant flow into a layer of tray.
Advantages of pharmaceutical intermediate double cone rotary vacuum dryer
The machine is easy to operate and convenient to feed and discharge, which greatly reduces the labor intensity of workers, and also reduces the environmental pollution of the materials in the drying process, improves product quality, and meets the requirements of the pharmaceutical management standard "GMP".
